Primary Identifier | MGI:2181295 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Bmpr1a |
Transmission | Germline | Strain of Origin | 129S7/SvEvBrd-Hprt1<+> |
Is Recombinase | false | Is Wild Type | false |
molecularNote | Homologous recombination introduced a floxed neomycin resistance cassette into intron 2, and a single loxP site into intron 1. Cre-mediated recombination in vivo under the control of a CMV promoter excised the neo cassette and exon 2, which encodes roughly a third of the extracellular domain of the receptor within the ligand-binding domain. |