| First Author | Maxwell MM | Year | 1995 |
| Journal | J Biol Chem | Volume | 270 |
| Issue | 42 | Pages | 25213-9 |
| PubMed ID | 7559658 | Mgi Jnum | J:29463 |
| Mgi Id | MGI:76997 | Doi | 10.1074/jbc.270.42.25213 |
| Citation | Maxwell MM, et al. (1995) Ke 6 gene. Sequence and organization and aberrant regulation in murine polycystic kidney disease. J Biol Chem 270(42):25213-9 |
| abstractText | Ke 6 gene is a newly identified gene located in the major histocompatibility complex and is a candidate steroid dehydrogenase gene because of structural homology and regulatory similarities with mammalian steroid dehydrogenases. We report here the complete nucleotide sequence and intron-exon organization of the Ke 6 gene and cloning of the alternatively spliced Ke 6b transcript. We find that Ke 6 gene expression is down-regulated in pcy mice which is a murine model of polycystic kidney disease (PKD). Thus far, Ke 6 gene expression is down-regulated in all murine models of PKD we have examined. Abnormal steroid metabolism as a possible cause of PKD is discussed. |
