| First Author | Sinclair C | Year | 2017 |
| Journal | Science | Volume | 357 |
| Issue | 6355 | Pages | 1014-1021 |
| PubMed ID | 28798047 | Mgi Jnum | J:244375 |
| Mgi Id | MGI:5913154 | Doi | 10.1126/science.aaj2155 |
| Citation | Sinclair C, et al. (2017) mTOR regulates metabolic adaptation of APCs in the lung and controls the outcome of allergic inflammation. Science 357(6355):1014-1021 |
| abstractText | Antigen-presenting cells (APCs) occupy diverse anatomical tissues, but their tissue-restricted homeostasis remains poorly understood. Here, working with mouse models of inflammation, we found that mechanistic target of rapamycin (mTOR)-dependent metabolic adaptation was required at discrete locations. mTOR was dispensable for dendritic cell (DC) homeostasis in secondary lymphoid tissues but necessary to regulate cellular metabolism and accumulation of CD103+ DCs and alveolar macrophages in lung. Moreover, while numbers of mTOR-deficient lung CD11b+ DCs were not changed, they were metabolically reprogrammed to skew allergic inflammation from eosinophilic T helper cell 2 (TH2) to neutrophilic TH17 polarity. The mechanism for this change was independent of translational control but dependent on inflammatory DCs, which produced interleukin-23 and increased fatty acid oxidation. mTOR therefore mediates metabolic adaptation of APCs in distinct tissues, influencing the immunological character of allergic inflammation. |
