| First Author | Iwase Y | Year | 2001 |
| Journal | Cancer Lett | Volume | 173 |
| Issue | 2 | Pages | 105-9 |
| PubMed ID | 11597783 | Mgi Jnum | J:72285 |
| Mgi Id | MGI:2152249 | Doi | 10.1016/s0304-3835(01)00615-2 |
| Citation | Iwase Y, et al. (2001) Inhibitory effect of flavonoid derivatives on Epstein-Barr virus activation and two-stage carcinogenesis of skin tumors. Cancer Lett 173(2):105-9 |
| abstractText | To search for possible anti-tumor promoters, ten flavonoid derivatives (1-10) synthesized from morin and quercetin were examined for their inhibitory effects on the Epstein-Barr virus early antigen (EBV-EA) activation by a short-term in vitro assay. Of these compounds, pentaallyl ethers (9, 10) showed significant inhibitory effects on EBV-EA activation induced by the tumor promoter, 12-O-tetradecanoylphorbol 13-acetate. Further, quercetin pentaallyl ether (10) exhibited remarkable inhibitory effects on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. |
