| First Author | Mitchell M | Year | 1989 |
| Journal | Genetics | Volume | 121 |
| Issue | 4 | Pages | 803-9 |
| PubMed ID | 2721933 | Mgi Jnum | J:9798 |
| Mgi Id | MGI:58255 | Doi | 10.1093/genetics/121.4.803 |
| Citation | Mitchell M, et al. (1989) Localization of murine X and autosomal sequences homologous to the human Y located testis-determining region. Genetics 121(4):803-9 |
| abstractText | Recently a candidate gene for the primary testis-determining factor (TDF) encoding a zinc finger protein (ZFY) has been cloned from the human Y chromosome. A highly homologous X-linked copy has also been identified. Using this human sequence it is possible to identify two Y loci, an X and an autosomal locus in the mouse (Zfy-1, Zfy-2, Zfx and Zfa, respectively). Suprisingly ZFY is more homologous to the mouse X and autosomal sequences than it is to either of the Y-linked loci. Both Zfy-1 and Zfy-2 are present in the Sxr region of the Y but Zfy-2 is absent in the Sxr deletion variant Sxrb (or Sxr) suggesting it is not necessary for male determination. Extensive backcross analyses map Zfa to mouse chromosome 10 and Zfx to a 5-cM interval between anonymous X probe MDXS120 and the tabby locus (Ta). We also show that the mouse androgen receptor locus (m-AR) believed to underlie the testicular feminization mutation (Tfm) shows complete linkage to Zfx. Comparative mapping indicates that in man these genes lie in separate conserved DNA segments. |
