| First Author | Nechanitzky R | Year | 2013 |
| Journal | Nat Immunol | Volume | 14 |
| Issue | 8 | Pages | 867-75 |
| PubMed ID | 23812095 | Mgi Jnum | J:205723 |
| Mgi Id | MGI:5546294 | Doi | 10.1038/ni.2641 |
| Citation | Nechanitzky R, et al. (2013) Transcription factor EBF1 is essential for the maintenance of B cell identity and prevention of alternative fates in committed cells. Nat Immunol 14(8):867-75 |
| abstractText | The transcription factors EBF1 and Pax5 have been linked to activation of the B cell lineage program and irreversible loss of alternative lineage potential (commitment), respectively. Here we conditionally deleted Ebf1 in committed pro-B cells after transfer into alymphoid mice. We found that those cells converted into innate lymphoid cells (ILCs) and T cells with variable-diversity-joining (VDJ) rearrangements of loci encoding both B cell and T cell antigen receptors. As intermediates in lineage conversion, Ebf1-deficient CD19(+) cells expressing Pax5 and transcriptional regulators of the ILC and T cell fates were detectable. In particular, genes encoding the transcription factors Id2 and TCF-1 were bound and repressed by EBF1. Thus, both EBF1 and Pax5 are required for B lineage commitment by repressing distinct and common determinants of alternative cell fates. |
