| First Author | Wang G | Year | 1997 |
| Journal | J Cell Sci | Volume | 110 ( Pt 4) |
| Pages | 505-13 | PubMed ID | 9067602 |
| Mgi Jnum | J:38843 | Mgi Id | MGI:86219 |
| Doi | 10.1242/jcs.110.4.505 | Citation | Wang G, et al. (1997) Syndet is a novel SNAP-25 related protein expressed in many tissues. J Cell Sci 110(Pt 4):505-13 |
| abstractText | SNAP-25 is a synaptosomal associated protein localized at the plasma membrane of nerve terminals. SNAP-25 associates with syntaxin 1 and vesicle-associated membrane protein-2 (VAMP-2) and is thought to form a complex essential for neurotransmitter release. We have identified syndet, a novel protein related to the family of SNAP-25 isoforms. Like SNAP-25, syndet has regions with high probability of forming coiled coils, a cysteine rich-domain, and lacks a signal sequence or transmembrane domains. Syndet is tightly bound to membranes, possibly by acylation within the cysteine-rich domain. Syndet is expressed in non-neuronal tissues. In adipocytes, syndet is found at the plasma membrane and in an intracellular compartment. The identification of syndet supports the hypothesis that multiple SNAP-25 related proteins ensure specificity of vesicle fusion at the cell surface. |
