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Protein Coding Gene : Rptor regulatory associated protein of MTOR, complex 1

Primary Identifier  MGI:1921620 Organism  mouse, laboratory
Chromosome  11 NCBI Gene Number  74370
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0)

Predicted to enable several functions, including 14-3-3 protein binding activity; enzyme binding activity; and protein kinase regulator activity. Involved in several processes, including TORC1 signaling; negative regulation of insulin secretion; and positive regulation of cell differentiation. Predicted to be located in several cellular components, including cytoplasmic stress granule; lysosome; and nucleoplasm. Predicted to be part of TORC1 complex. Predicted to be active in lysosomal membrane. Predicted to colocalize with dendrite and neuronal cell body. Is expressed in several structures, including cardiovascular system; early conceptus; endocrine gland; genitourinary system; and nervous system. Human ortholog(s) of this gene implicated in nicotine dependence. Orthologous to human RPTOR (regulatory associated protein of MTOR complex 1).
PHENOTYPE: Homozygous mutation of this gene results in lethality prior to somitogenesis. Mice homozygous for a conditional allele activated in dendritic cells exhibit increased susceptibility to induced colitis and expansion of certain populations of dendritic cells. [provided by MGI curators]
  • synonyms:
  • Rap,
  • mKIAA1303,
  • Rptor,
  • regulatory associated protein of MTOR, complex 1,
  • 4932417H02Rik,
  • raptor,
  • RIKEN cDNA 4932417H02 gene

Features --> Cross References

Genome

Sequence Feature Displayer

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

0 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

21 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

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0 Driver For