| Primary Identifier | IPR026057 | Type | Family |
| Short Name | PC-Esterase |
| description | The PC-Esterase family []is comprised of Cas1p, the Homo sapiens C7orf58, Arabidopsis thaliana PMR5 and a group of plant freezing resistance/cold acclimatization proteins typified by Arabidopsis thaliana ESKIMO1 (also known as XOAT1) [, ], animal FAM55D proteins, and animal FAM113 proteins. The PC-Esterase family has features that are both similar and different from the canonical GDSL/SGNH superfamily []. The members of this family are predicted to have Acyl esterase activity and predicted to modify cell-surface biopolymers such as glycans and glycoproteins [, ]. The Cas1p protein has a Cas1_AcylT domain, in addition, with the opposing acyltransferase activity []. The C7orf58 family has a ATP-Grasp domain fused to the PC-Esterase and is the first identified secreted tubulin-tyrosine ligase like enzyme in eukaryotes []. The plant family with PMR5, XOAT1, TBL3 etc have an N-terminal C rich potential sugar binding domain followed by the PC-Esterase domain [].In Arabidopsis, XOAT1 catalyzes the 2-O-acetylation of xylan, followed by nonenzymatic acetyl migration to the O-3 position, resulting in products that are monoacetylated at both O-2 and O-3 positions [, ]. Its role is essential for the production of functional xylem vessels [, ]. It functions as a negative regulator of cold acclimation, and mutations in the ESK1 gene provides strong freezing tolerance []. |
