Primary Identifier | MGI:6330764 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Pth2r |
Transmission | Germline | Strain of Origin | (129 x C57BL/6)F1 |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A loxP site was inserted into intron 4 and a neomycin resistance gene cassette and a second loxP site into intron 5. The floxed exon 5 and the neo cassette were deleted through subsequent cre-mediated recombination. Exon 5 contains a transmembrane domain and its deletion causes a frameshift, creating a null allele. |