| Primary Identifier | IPR028734 | Type | Family |
| Short Name | LIMD1 |
| description | LIM domain-containing protein 1 (LIMD1) is an adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organisation, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration [, , ]. LIMD1 is a critical tumor suppressor involved in human lung cancer development [], and reduced expression has also been demonstrated in breast and head and neck squamous cell carcinomas [, ]. LIMD1 binds the retinoblastoma protein (pRB) and acts as a co-repressor of E2F-driven transcription []. |
