| First Author | Park SY | Year | 2021 |
| Journal | Nat Commun | Volume | 12 |
| Issue | 1 | Pages | 2923 |
| PubMed ID | 34011956 | Mgi Jnum | J:306334 |
| Mgi Id | MGI:6713917 | Doi | 10.1038/s41467-021-23277-8 |
| Citation | Park SY, et al. (2021) Club cell-specific role of programmed cell death 5 in pulmonary fibrosis. Nat Commun 12(1):2923 |
| abstractText | Idiopathic pulmonary fibrosis (IPF) causes progressive fibrosis and worsening pulmonary function. Prognosis is poor and no effective therapies exist. We show that programmed cell death 5 (PDCD5) expression is increased in the lungs of patients with IPF and in mouse models of lung fibrosis. Lung fibrosis is significantly diminished by club cell-specific deletion of Pdcd5 gene. PDCD5 mediates beta-catenin/Smad3 complex formation, promoting TGF-beta-induced transcriptional activation of matricellular genes. Club cell Pdcd5 knockdown reduces matricellular protein secretion, inhibiting fibroblast proliferation and collagen synthesis. Here, we demonstrate the club cell-specific role of PDCD5 as a mediator of lung fibrosis and potential therapeutic target for IPF. |
