| Primary Identifier | MGI:2384854 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 213389 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables DNA binding activity; histone H3 methyltransferase activity; and protein homodimerization activity. Involved in several processes, including male gamete generation; meiosis I; and positive regulation of fertilization. Acts upstream of or within several processes, including positive regulation of meiotic nuclear division; positive regulation of transcription by RNA polymerase II; and spermatogenesis. Located in nucleus. Part of chromatin. Is expressed in embryo; head; ovary; and testis. Orthologous to several human genes including PRDM9 (PR/SET domain 9). PHENOTYPE: Mice homozygous for a knock-out allele show decreased oocyte number, azoospermia, and sterility in both sexes due to severe impairment of the double-stranded break repair pathway, deficient pairing of homologous chromosomes, and impaired sex body formation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
