| First Author | Conti HR | Year | 2016 |
| Journal | Cell Host Microbe | Volume | 20 |
| Issue | 5 | Pages | 606-617 |
| PubMed ID | 27923704 | Mgi Jnum | J:281520 |
| Mgi Id | MGI:6378833 | Doi | 10.1016/j.chom.2016.10.001 |
| Citation | Conti HR, et al. (2016) IL-17 Receptor Signaling in Oral Epithelial Cells Is Critical for Protection against Oropharyngeal Candidiasis. Cell Host Microbe 20(5):606-617 |
| abstractText | Signaling through the IL-17 receptor (IL-17R) is required to prevent oropharyngeal candidiasis (OPC) in mice and humans. However, the IL-17-responsive cell type(s) that mediate protection are unknown. Using radiation chimeras, we were able to rule out a requirement for IL-17RA in the hematopoietic compartment. We saw remarkable concordance of IL-17-controlled gene expression in C. albicans-infected human oral epithelial cells (OECs) and in tongue tissue from mice with OPC. To interrogate the role of the IL-17R in OECs, we generated mice with conditional deletion of IL-17RA in superficial oral and esophageal epithelial cells (Il17ra(DeltaK13)). Following oral Candida infection, Il17ra(DeltaK13) mice exhibited fungal loads and weight loss indistinguishable from Il17ra(-/-) mice. Susceptibility in Il17ra(DeltaK13) mice correlated with expression of the antimicrobial peptide beta-defensin 3 (BD3, Defb3). Consistently, Defb3(-/-) mice were susceptible to OPC. Thus, OECs dominantly control IL-17R-dependent responses to OPC through regulation of BD3 expression. |
