| First Author | Imanishi T | Year | 2014 |
| Journal | Nat Commun | Volume | 5 |
| Pages | 3566 | PubMed ID | 24717539 |
| Mgi Jnum | J:213251 | Mgi Id | MGI:5583942 |
| Doi | 10.1038/ncomms4566 | Citation | Imanishi T, et al. (2014) Nucleic acid sensing by T cells initiates Th2 cell differentiation. Nat Commun 5:3566 |
| abstractText | While T-cell responses are directly modulated by Toll-like receptor (TLR) ligands, the mechanism and physiological function of nucleic acids (NAs)-mediated T cell costimulation remains unclear. Here we show that unlike in innate cells, T-cell costimulation is induced even by non-CpG DNA and by self-DNA, which is released from dead cells and complexes with antimicrobial peptides or histones. Such NA complexes are internalized by T cells and induce costimulatory responses independently of known NA sensors, including TLRs, RIG-I-like receptors (RLRs), inflammasomes and STING-dependent cytosolic DNA sensors. Such NA-mediated costimulation crucially induces Th2 differentiation by suppressing T-bet expression, followed by the induction of GATA-3 and Th2 cytokines. These findings unveil the function of NA sensing by T cells to trigger and amplify allergic inflammation. |
