| First Author | Wang ZM | Year | 1998 |
| Journal | Proc Natl Acad Sci U S A | Volume | 95 |
| Issue | 26 | Pages | 15583-6 |
| PubMed ID | 9861012 | Mgi Jnum | J:119885 |
| Mgi Id | MGI:3703414 | Doi | 10.1073/pnas.95.26.15583 |
| Citation | Wang ZM, et al. (1998) Endogenous E2F-1 promotes timely G0 exit of resting mouse embryo fibroblasts. Proc Natl Acad Sci U S A 95(26):15583-6 |
| abstractText | Much evidence strongly suggests a positive role for one or more E2F species in the control of exit from G0/G1. Results described here provide direct evidence that endogenous E2F-1, as predicted, contributes to progression from G0 to S. By contrast, cycling cells lacking an intact E2F-1 gene demonstrated normal cell cycle distribution. Therefore, E2F-1 exerts a unique function leading to timely G0 exit of resting cultured primary cells, while at the same time being unnecessary for normal G1 to S phase progression of cycling cells. |
