| Primary Identifier | IPR010868 | Type | Family |
| Short Name | Tumor_suppres_ARF |
| description | ARF (also known as p14ARF in the human and p19ARF in the mouse) is an alternative transcript of the INK4a/ARF tumour-suppressor locus that encodes p16INK4a, an inhibitor of cyclin dependent kinases. ARFs are tumour suppressors participating in p53-dependent or independent pathways that restrain abnormal cell growth and maintain genomic stability [, , ]. ARF interacts with MDM2 and neutralizes MDM2's inhibition of p53 []. Mdm2 may also regulate ARF turnover by mediating its degradation through the proteasome []. p14ARF has also been shown to interact with E2F factors to form p14ARF-E2F/partner-DNA complexes repressing E2F-dependent transcription []. |
