| Primary Identifier | IPR029420 | Type | Domain |
| Short Name | MTBP_central |
| description | This entry represents the central domain of the MDM2-binding protein (MTBP). MDM2 is an E3 ubiquitin-protein ligase that mediates ubiquitination of p53, leading to its degradation by the proteasome []. MTBP inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability, and this promotes MDM2-mediated ubiquitination of p53 and its subsequent degradation []. Mouse MTBP also inhibits cancer cell migration by interacting with alpha-actinin-4 (ACTN4) []. |
