| First Author | McNab AR | Year | 1989 |
| Journal | J Invest Dermatol | Volume | 92 |
| Issue | 2 | Pages | 263-6 |
| PubMed ID | 2465353 | Mgi Jnum | J:19084 |
| Mgi Id | MGI:67283 | Doi | 10.1111/1523-1747.ep12276832 |
| Citation | McNab AR, et al. (1989) An ultra-high sulfur keratin gene is expressed specifically during hair growth. J Invest Dermatol 92(2):263-6 |
| abstractText | To study the regulation of the hair cycle in the mouse, we have isolated and characterized a gene for ultra high sulfur keratin that is expressed specifically during the active hair growth cycle. The gene (gUHSK-704Eco) was isolated as a member of a gene cluster on a recombinant phage with a DNA insert of 18 kb that was isolated by screening a murine genomic library at low stringency with a synthetic oligonucleotide derived from a sheep high sulfur keratin gene (Powell, Nucleic Acids Res. 1983 11, 5327). The murine ultra-high sulfur keratin gene has no intervening sequence; the 558 nucleotide of the coding region specify 186 amino acids, of which 70 (37%) are cysteine. A Cys-Cys-Gln-Pro repeat is found 12 times within the coding region. RNA dot blots show that the ultra-high sulfur keratin gene is expressed during the hair cycle concomitant with the anterior-posterior temporal pattern of the normal murine hair cycle. |
