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Publication : Pericytes: developmental, physiological, and pathological perspectives, problems, and promises.

First Author  Armulik A Year  2011
Journal  Dev Cell Volume  21
Issue  2 Pages  193-215
PubMed ID  21839917 Mgi Jnum  J:193884
Mgi Id  MGI:5469827 Doi  10.1016/j.devcel.2011.07.001
Citation  Armulik A, et al. (2011) Pericytes: developmental, physiological, and pathological perspectives, problems, and promises. Dev Cell 21(2):193-215
abstractText  Pericytes, the mural cells of blood microvessels, have recently come into focus as regulators of vascular morphogenesis and function during development, cardiovascular homeostasis, and disease. Pericytes are implicated in the development of diabetic retinopathy and tissue fibrosis, and they are potential stromal targets for cancer therapy. Some pericytes are probably mesenchymal stem or progenitor cells, which give rise to adipocytes, cartilage, bone, and muscle. However, there is still confusion about the identity, ontogeny, and progeny of pericytes. Here, we review the history of these investigations, indicate emerging concepts, and point out problems and promise in the field of pericyte biology.
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