| First Author | Angelin-Duclos C | Year | 2002 |
| Journal | Eur J Immunol | Volume | 32 |
| Issue | 12 | Pages | 3765-75 |
| PubMed ID | 12516571 | Mgi Jnum | J:80860 |
| Mgi Id | MGI:2447291 | Doi | 10.1002/1521-4141(200212)32:12<3765::AID-IMMU3765>3.0.CO;2-I |
| Citation | Angelin-Duclos C, et al. (2002) An interfering form of Blimp-1 increases IgM secreting plasma cells and blocks maturation of peripheral B cells. Eur J Immunol 32(12):3765-75 |
| abstractText | B lymphocyte-induced maturation protein-1 (Blimp-1) can drive plasmacytic differentiation in cultured cell models. To determine the role of Blimp-1 in B cell development in vivo, we have generated transgenic mice expressing an interfering truncated form of Blimp-1 (TBlimp) under the control of an immunoglobulin heavy chain promoter and intronic (E) enhancer. TBlimp-transgenic mice have elevated serum IgM and a prolonged IgM response. This effect is due to an increased number of short-lived, IgM-secreting plasma cells resulting from increased proliferation and prolonged survival. In addition, TBlimp-transgenic mice have a developmental defect in the generation of mature B cells in the spleen. These results show that in vivo Blimp-1 plays a fundamental role in the control of the life span and exit from the cell cycle of IgM secreting plasma cells. |
