| First Author | Chen Y | Year | 2011 |
| Journal | J Exp Med | Volume | 208 |
| Issue | 5 | Pages | 923-35 |
| PubMed ID | 21502331 | Mgi Jnum | J:177305 |
| Mgi Id | MGI:5294719 | Doi | 10.1084/jem.20101192 |
| Citation | Chen Y, et al. (2011) Critical role for Gimap5 in the survival of mouse hematopoietic stem and progenitor cells. J Exp Med 208(5):923-35 |
| abstractText | Mice and rats lacking the guanosine nucleotide-binding protein Gimap5 exhibit peripheral T cell lymphopenia, and Gimap5 can bind to Bcl-2. We show that Gimap5-deficient mice showed progressive multilineage failure of bone marrow and hematopoiesis. Compared with wild-type counterparts, Gimap5-deficient mice contained more hematopoietic stem cells (HSCs) but fewer lineage-committed hematopoietic progenitors. The reduction of progenitors and differentiated cells in Gimap5-deficient mice resulted in a loss of HSC quiescence. Gimap5-deficient HSCs and progenitors underwent more apoptosis and exhibited defective long-term repopulation capacity. Absence of Gimap5 disrupted interaction between Mcl-1-which is essential for HSC survival-and HSC70, enhanced Mcl-1 degradation, and compromised mitochondrial integrity in progenitor cells. Thus, Gimap5 is an important stabilizer of mouse hematopoietic progenitor cell survival. |
