| Primary Identifier | IPR030029 | Type | Family |
| Short Name | GRIP2 |
| description | This entry represent GRIP2. In mice GRIP2 functions downstream of Notch3/RBP-Jkappa to regulate myogenic tone in the brain arteries []. In Xenopus GRIP2 is involved in primordial germ cell development and migration []. Glutamate receptor-interacting proteins (GRIPs) are multi-PDZ domain scaffolding proteins required for dendrite development. There are two members of the GRIP family: GRIP1 and GRIP2/ABP (AMPA receptor binding protein) []. GRIPs regulate AMPAR receptor trafficking and neuronal plasticity [, ]. They also bind various receptor and signalling proteins, such as EphB receptors, ephrinB ligands, the proteoglycan NG2, the Fraser syndrome protein Fras1, and matrix metalloproteinase 5 []. |
