| Primary Identifier | MGI:2451256 | Allele Type | Targeted |
| Attribute String | Inserted expressed sequence, Null/knockout | Gene | Apoa1 |
| Transmission | Germline | Strain of Origin | 129X1/SvJ |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Human APOA1 sequence carrying the milano missense mutation (R173C) which is associated with a reduced risk for cardiovascular disease was inserted into the endogenous locus via homologous recombination. Murine exons 2 through 3 were replaced with human exons 2 through 4, while murine exon 4 was disrupted by a neomycin selection cassette. |
