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Protein Coding Gene : Eef2 eukaryotic translation elongation factor 2
Primary Identifier  MGI:95288 Organism  mouse, laboratory
Chromosome  10 NCBI Gene Number  13629
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Enables GTPase activity. Acts upstream of or within hematopoietic progenitor cell differentiation and translational elongation. Located in cytoplasm and ribosome. Is active in synapse. Is expressed in brain and neocortex. Human ortholog(s) of this gene implicated in glaucoma; spinocerebellar ataxia type 26; and stomach cancer. Orthologous to human EEF2 (eukaryotic translation elongation factor 2).
PHENOTYPE: Mice homozygous for a mutation removing the diphthamide modification display partial neonatal lethality, fetal growth retardation and abnormal cell physiology. [provided by MGI curators]
  • synonyms:
  • Eef2,
  • elongation factor 2,
  • MGD-MRK-9309,
  • Ef-2,
  • eukaryotic translation elongation factor 2,
  • MGD-MRK-9307
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1 Involved In Mutations

Trail: ProteinCodingGene

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0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

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Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

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11 Pathways

Trail: ProteinCodingGene

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Gene --> Protein-Protein Interactions

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Phenotype

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Disease

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