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Publication : Gene transpositions in the HoxD complex reveal a hierarchy of regulatory controls.

First Author  van der Hoeven F Year  1996
Journal  Cell Volume  85
Issue  7 Pages  1025-35
PubMed ID  8674109 Mgi Jnum  J:33879
Mgi Id  MGI:81372 Doi  10.1016/s0092-8674(00)81303-3
Citation  van der Hoeven F, et al. (1996) Gene transpositions in the HoxD complex reveal a hierarchy of regulatory controls. Cell 85(7):1025-35
abstractText  Vertebrate Hox genes are activated following a temporal sequence that reflects their linear order in the clusters. We introduced two Hoxd transcription units, labeled with lacZ, to an ectopic 5' position in the HoxD complex. Early expression of the relocated genes was delayed and resembled that of the neighboring Hoxd-13. At later stages, locus-dependent expression in distal limbs and the genital eminence was observed, indicating that common
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