First Author | van der Hoeven F | Year | 1996 |
Journal | Cell | Volume | 85 |
Issue | 7 | Pages | 1025-35 |
PubMed ID | 8674109 | Mgi Jnum | J:33879 |
Mgi Id | MGI:81372 | Doi | 10.1016/s0092-8674(00)81303-3 |
Citation | van der Hoeven F, et al. (1996) Gene transpositions in the HoxD complex reveal a hierarchy of regulatory controls. Cell 85(7):1025-35 |
abstractText | Vertebrate Hox genes are activated following a temporal sequence that reflects their linear order in the clusters. We introduced two Hoxd transcription units, labeled with lacZ, to an ectopic 5' position in the HoxD complex. Early expression of the relocated genes was delayed and resembled that of the neighboring Hoxd-13. At later stages, locus-dependent expression in distal limbs and the genital eminence was observed, indicating that common |