| Primary Identifier | IPR045663 | Type | Domain |
| Short Name | ORC3_ins |
| description | This is the insertion domain of ORC subunit 3 (ORC3) predominantly found in chodates, arthropodes and vertebrates, located between the N-terminal AAA+-like subunit and the C-terminal winged-helix (WH) DNA-binding domain []. ORC3 is a component of the origin recognition complex (ORC) that binds origins of replication, required to assemble the pre-replication complex necessary to initiate DNA replication. This insertion domain forms a bi-lobed α-helical protuberancethat engages a short α-helix formed at the ORC6 C-terminal, allowing its binding to ORC1-5 subunits [], which constitute the ORC core [, ]. |
