| First Author | Philip M | Year | 2017 |
| Journal | Nature | Volume | 545 |
| Issue | 7655 | Pages | 452-456 |
| PubMed ID | 28514453 | Mgi Jnum | J:252523 |
| Mgi Id | MGI:6093614 | Doi | 10.1038/nature22367 |
| Citation | Philip M, et al. (2017) Chromatin states define tumour-specific T cell dysfunction and reprogramming. Nature 545(7655):452-456 |
| abstractText | Tumour-specific CD8 T cells in solid tumours are dysfunctional, allowing tumours to progress. The epigenetic regulation of T cell dysfunction and therapeutic reprogrammability (for example, to immune checkpoint blockade) is not well understood. Here we show that T cells in mouse tumours differentiate through two discrete chromatin states: a plastic dysfunctional state from which T cells can be rescued, and a fixed dysfunctional state in which the cells are resistant to reprogramming. We identified surface markers associated with each chromatin state that distinguished reprogrammable from non-reprogrammable PD1(hi) dysfunctional T cells within heterogeneous T cell populations from tumours in mice; these surface markers were also expressed on human PD1(hi) tumour-infiltrating CD8 T cells. Our study has important implications for cancer immunotherapy as we define key transcription factors and epigenetic programs underlying T cell dysfunction and surface markers that predict therapeutic reprogrammability. |
