| First Author | Diaz P | Year | 1994 |
| Journal | Immunity | Volume | 1 |
| Issue | 3 | Pages | 207-17 |
| PubMed ID | 7889409 | Mgi Jnum | J:330515 |
| Mgi Id | MGI:7378769 | Doi | 10.1016/1074-7613(94)90099-x |
| Citation | Diaz P, et al. (1994) A locus control region in the T cell receptor alpha/delta locus. Immunity 1(3):207-17 |
| abstractText | A locus control region (LCR) is a set of cis-acting elements that regulate chromatin accessibility of a gene locus. In the T cell receptor (TCR) alpha/delta locus, an LCR might regulate the differential tissue and developmental expression and the rearrangement of TCR alpha and delta genes. We have localized a region 3' of the TCR alpha/delta locus containing eight T cell-specific nuclease hypersensitive domains (HS-1 to HS-8), which fit the characteristics of an LCR. In transgenic mice, a TCR alpha gene linked to this region is expressed at a high level, independent of the site of integration and correlates with gene copy number. The transgene is expressed in the alpha beta but not the gamma delta T cell subset and is activated at the right time during development. Proper LCR function requires the region containing HS-2 to HS-6. We propose a model of LCR competition to explain the differential regulation of TCR alpha versus delta genes during development. |
