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Publication : Developmental expression of voltage-sensitive K+ channels in mouse skeletal muscle and C2C12 cells.

First Author  Lesage F Year  1992
Journal  FEBS Lett Volume  310
Issue  2 Pages  162-6
PubMed ID  1383027 Mgi Jnum  J:2710
Mgi Id  MGI:51232 Doi  10.1016/0014-5793(92)81320-l
Citation  Lesage F, et al. (1992) Developmental expression of voltage-sensitive K+ channels in mouse skeletal muscle and C2C12 cells. FEBS Lett 310(2):162-6
abstractText  The developmental expression of voltage-sensitive K+ channels was analyzed by Northern blot in mouse skeletal muscle. Of nine Shaker-like genes studied, eight are expressed in this mammalian muscle. Their expression is differentially regulated during development. The mouse cell line C2C12 has been used to study expression of voltage-sensitive K+ channels during in vitro myotube differentiation. Different voltage-sensitive K+ channel messages are also expressed in these cells which display a pattern of expression depending upon the differentiation stage. The message for the very peculiar K+ channel of IsK type could only be detected by polymerase chain reaction on skeletal muscle mRNA.
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