| First Author | Townsend JM | Year | 2000 |
| Journal | Immunity | Volume | 13 |
| Issue | 4 | Pages | 573-83 |
| PubMed ID | 11070175 | Mgi Jnum | J:82881 |
| Mgi Id | MGI:2655902 | Doi | 10.1016/s1074-7613(00)00056-x |
| Citation | Townsend JM, et al. (2000) IL-9-deficient mice establish fundamental roles for IL-9 in pulmonary mastocytosis and goblet cell hyperplasia but not T cell development. Immunity 13(4):573-83 |
| abstractText | Interleukin-9 is a cytokine produced by Th2 cells and is a candidate gene for asthma and atopy. We have generated IL-9-deficient mice to delineate the specific roles of IL-9 in Th2 responses. Using a pulmonary granuloma model, we have demonstrated a distinct requirement for IL-9 in the rapid and robust generation of pulmonary goblet cell hyperplasia and mastocytosis in response to lung challenge. In contrast, eosinophilia and granuloma formation were not affected. IL-9 was not required for T cell development or differentiation, the generation of naive or antigen-driven antibody responses, or the expulsion of the intestinal parasitic nematode Nippostrongylus brasiliensis. Thus, deletion of IL-9 manifests as a highly defined phenotype in Th2 responses modulating mucus production and mast cell proliferation. |
