| First Author | Liang TJ | Year | 1996 |
| Journal | J Clin Invest | Volume | 97 |
| Issue | 12 | Pages | 2872-7 |
| PubMed ID | 8675700 | Mgi Jnum | J:71573 |
| Mgi Id | MGI:2150446 | Doi | 10.1172/JCI118744 |
| Citation | Liang TJ, et al. (1996) Transgenic expression of tpr-met oncogene leads to development of mammary hyperplasia and tumors. J Clin Invest 97(12):2872-7 |
| abstractText | Receptor tyrosine kinases are important in cell signal transduction and proliferation. Abnormal expression of tyrosine kinases often leads to malignant transformation. C-met is a tyrosine kinase receptor and its ligand is hepatocyte growth factor (HGF). HGF/c-met plays diverse role in regulation of cell growth, shape and movement. Constitutively activated met, such as tpr-met, is a potent oncogene in vitro, but its carcinogenic role in vivo remains unclear. Our study demonstrates that expression of tpr-met leads to development of mammary tumors and other malignancies in transgenic mice, and suggests that deregulated met expression may be involved in mammary carcinogenesis. |
