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Protein Domain : Potassium voltage-gated channel subfamily H member 5

Primary Identifier  IPR030171 Type  Family
Short Name  EAG2
description  This entry includes EAG2 (KCNH5, KV10.2) from mammals. Human EAG2 is expressed in the brain, but is also found in a range of tissues including skeletal muscle []. In medulloblastoma, it controls mitotic entry and tumour growth via regulating cell volume dynamics []. The voltage-gated potassium channel ether-a-go-go (eag) was first identified in Drosophila melanogaster based on the leg-shaking mutant phenotype [, ]. Later, the EAG (Ether-a-go-go) voltage-dependent potassium channel family was classified into 3 subfamilies: EAG, EAG-related gene (ERG), and EAG-like K+ channel (ELK). The mammalian EAG subfamily comprises of two members, termed EAG1 (KCNH1, KV10.1) and EAG2 (KCNH5, KV10.2) [].

0 Child Features

1 Parent Features

2 Protein Domain Regions