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GO Term : 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity [GO:0035539] Gene Ontology
Namespace  molecular_function Obsolete  false
description  Catalysis of the reaction: 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate (8-oxo-dGTP) + H2O = 8-oxo-7,8-dihydrodeoxyguanosine phosphate (8-oxo-dGMP) + diphosphate. 8-oxo-dGTP is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for DNA synthesis causing transversion mutations. 8-oxo-dGTPase hydrolyses 8-oxo-dGTP to its monophosphate form to prevent the misincorporation of 8-oxo-dGTP into cellular DNA.
  • synonyms:
  • 8-oxo-7,8-dihydro-deoxyguanosine triphosphate pyrophosphatase activity,
  • 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate pyrophosphohydrolase activity,
  • 8-oxo-dGTPase activity,
  • 8-oxo-7,8-dihydrodeoxyguanosine triphosphatase activity,
  • 8-oxo-dGTP pyrophosphohydrolase activity
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