| First Author | Kaya F | Year | 2008 |
| Journal | FEBS Lett | Volume | 582 |
| Issue | 25-26 | Pages | 3614-8 |
| PubMed ID | 18835269 | Mgi Jnum | J:141439 |
| Mgi Id | MGI:3818253 | Doi | 10.1016/j.febslet.2008.09.040 |
| Citation | Kaya F, et al. (2008) Ascorbic acid is a regulator of the intracellular cAMP concentration: old molecule, new functions?. FEBS Lett 582(25-26):3614-8 |
| abstractText | Recently, using an animal model of Charcot-Marie-Tooth human disorder, we showed that ascorbic acid (AA) represses PMP22 gene expression by acting on intracellular cAMP concentrations. In this work, we present kinetics data on the inhibitory effect of AA upon adenylate cyclase activity. The data show that this molecule acts as a competitive inhibitor of the enzyme, a finding that opens new pharmacological avenues. |
