| First Author | Acevedo L | Year | 2004 |
| Journal | Nat Med | Volume | 10 |
| Issue | 4 | Pages | 382-8 |
| PubMed ID | 15034570 | Mgi Jnum | J:90093 |
| Mgi Id | MGI:3042512 | Doi | 10.1038/nm1020 |
| Citation | Acevedo L, et al. (2004) A new role for Nogo as a regulator of vascular remodeling. Nat Med 10(4):382-8 |
| abstractText | Although Nogo-A has been identified in the central nervous system as an inhibitor of axonal regeneration, the peripheral roles of Nogo isoforms remain virtually unknown. Here, using a proteomic analysis to identify proteins enriched in caveolae and/or lipid rafts (CEM/LR), we show that Nogo-B is highly expressed in cultured endothelial and smooth muscle cells, as well as in intact blood vessels. The N terminus of Nogo-B promotes the migration of endothelial cells but inhibits the migration of vascular smooth muscle (VSM) cells, processes necessary for vascular remodeling. Vascular injury in Nogo-A/B-deficient mice promotes exaggerated neointimal proliferation, and adenoviral-mediated gene transfer of Nogo-B rescues the abnormal vascular expansion in those knockout mice. Our discovery that Nogo-B is a regulator of vascular homeostasis and remodeling broadens the functional scope of this family of proteins. |
