| First Author | Anunciado RV | Year | 2001 |
| Journal | Exp Anim | Volume | 50 |
| Issue | 4 | Pages | 319-24 |
| PubMed ID | 11515095 | Mgi Jnum | J:71465 |
| Mgi Id | MGI:2150206 | Doi | 10.1538/expanim.50.319 |
| Citation | Anunciado RV, et al. (2001) Quantitative trait loci for body weight in the intercross between SM/J and A/J mice. Exp Anim 50(4):319-24 |
| abstractText | We performed a genome-wide quantitative trait locus (QTL) analysis of body weight at 10 weeks of age in a population of 321 intercross offspring from SM/J and A/J mice, progenitor strains of SMXA recombinant inbred strains. Interval mapping revealed two significant QTLs, Bwq3 (body weight QTL3) and Bwq4, on Chromosomes (Chrs) 8 and 18 respectively, and five suggestive QTLs on Chrs 2, 6, 7, 15 and 19. Bwq3 and Bwq4 explained 6% of the phenotypic variance. The SM/J alleles at both QTLs increased body weight, though the SM/J mouse was smaller than the A/J mouse. On the other hand, four of the five suggestive QTLs detected had male-specific effects on body weight and the remainder was female-specific. These suggestive QTLs explained 5-6% of the phenotypic variance and all the SM/J alleles decreased body weight. |
