| First Author | Yaswen P | Year | 2007 |
| Journal | Cell | Volume | 128 |
| Issue | 2 | Pages | 233-4 |
| PubMed ID | 17254959 | Mgi Jnum | J:121487 |
| Mgi Id | MGI:3710275 | Doi | 10.1016/j.cell.2007.01.005 |
| Citation | Yaswen P, et al. (2007) Oncogene-induced senescence pathways weave an intricate tapestry. Cell 128(2):233-4 |
| abstractText | The induction of cellular senescence by activated oncogenes acts as a barrier to cell transformation. Now, identify a key component of a senescence pathway that prevents tumorigenesis in a mouse model of skin cancer. They show that the p38-regulated/activated protein kinase (PRAK) induces senescence downstream of oncogenic Ras by directly phosphorylating and activating the tumor-suppressor protein p53. |
