| Primary Identifier | IPR037427 | Type | Domain |
| Short Name | SNX33_BAR |
| description | Sorting nexins are a large family of evolutionarily conserved phosphoinositide-binding proteins that have roles in cargo sorting through the endosomal netwrok []. Sorting nexins contain at least a PX domain (a phospholipid-binding motif). Some nexins contain a few additional domains. Proteins in the sorting nexin 9 subfamily includes SNX9, SNX18 and SNX33 []. They are characterised by the presence of an N-terminal SH3 domain (), a PX domain that is a phosphoinositide-binding module (), and a Bin/Amphiphysin/Rvs (BAR) domain at the C terminus, which allows membrane binding and bending. They are required for progression and completion of mitosis []. SNX33 plays a role in maintaining cell shape and cell cycle progression through its interaction with WASp (Wiskott-Aldrich syndrome protein) []. It interferes with cellular prion protein (PrP) formation by modulation of its shedding []. It may also promote the formation of macropinosomes (large endocytic organelles) []. This entry represents the BAR domain of SNX33. BAR domains are dimerization, lipid binding and curvature sensing modules found in many different proteins with diverse functions []. |
