Primary Identifier | MGI:1343101 | Organism | mouse, laboratory |
Chromosome | 11 | NCBI Gene Number | 14534 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0) Enables DNA-binding transcription factor binding activity; chromatin binding activity; and histone acetyltransferase activity. Involved in several processes, including long-term memory; positive regulation of macromolecule biosynthetic process; and regulation of regulatory T cell differentiation. Acts upstream of or within several processes, including brain development; chordate embryonic development; and positive regulation of gluconeogenesis. Located in mitotic spindle and nucleus. Part of ATAC complex and SAGA complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and hemolymphoid system gland. Orthologous to human KAT2A (lysine acetyltransferase 2A). PHENOTYPE: Homozygotes for targeted null mutations exhibit poorly developed yolk sac blood vessels, retarded growth, absence of dorsal mesoderm lineages, failure to form somites, and lethality between embryonic days 9.5-11.5. [provided by MGI curators] |