Primary Identifier | MGI:1345184 | Organism | mouse, laboratory |
Chromosome | 11 | NCBI Gene Number | 23964 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables protein heterodimerization activity and protein homodimerization activity. Predicted to be involved in axon guidance; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; and retrograde trans-synaptic signaling by trans-synaptic protein complex. Predicted to act upstream of or within cell adhesion. Predicted to be located in cell-cell junction; dendritic spine; and postsynaptic membrane. Predicted to be active in glutamatergic synapse and neuron projection. Predicted to be extrinsic component of postsynaptic membrane. Is expressed in several structures, including alimentary system; integumental system; nervous system; sensory organ; and skeleton. Orthologous to human TENM2 (teneurin transmembrane protein 2). PHENOTYPE: Mice homozygous for a null allele show abnormalities in the laterality and mapping of ipsilateral retinal projections that lead to loss of ipsilateral drive, defects in binocular vision, and impaired performance on a visual discrimination task. [provided by MGI curators] |