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Protein Coding Gene : Usp22 ubiquitin specific peptidase 22

Primary Identifier  MGI:2144157 Organism  mouse, laboratory
Chromosome  11 NCBI Gene Number  216825
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0)

Enables cysteine-type deubiquitinase activity. Predicted to be involved in positive regulation of DNA-templated transcription; positive regulation of mitotic cell cycle; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within ubiquitin-dependent protein catabolic process. Predicted to be located in nucleus. Predicted to be part of SAGA complex. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and respiratory system. Orthologous to human USP22 (ubiquitin specific peptidase 22).
PHENOTYPE: Mice homozygous for a null allele exhibit embryonic lethality, embryonic growth retardation, placental defects, and increased apoptosis in mouse embryonic fibroblasts. Homozygotes for a hypomorphic allele are viable but show postnatal growth retardation, and impaired cell differentiation in the small intestine and brain. [provided by MGI curators]
  • synonyms:
  • expressed sequence AI427806,
  • Usp22,
  • ubiquitin specific peptidase 22,
  • AI427806

Features --> Cross References

Genome

Sequence Feature Displayer

JG Browse Displayer

0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

3 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

4 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

0 Driver For