Primary Identifier | MGI:2144157 | Organism | mouse, laboratory |
Chromosome | 11 | NCBI Gene Number | 216825 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables cysteine-type deubiquitinase activity. Predicted to be involved in positive regulation of DNA-templated transcription; positive regulation of mitotic cell cycle; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within ubiquitin-dependent protein catabolic process. Predicted to be located in nucleus. Predicted to be part of SAGA complex. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and respiratory system. Orthologous to human USP22 (ubiquitin specific peptidase 22). PHENOTYPE: Mice homozygous for a null allele exhibit embryonic lethality, embryonic growth retardation, placental defects, and increased apoptosis in mouse embryonic fibroblasts. Homozygotes for a hypomorphic allele are viable but show postnatal growth retardation, and impaired cell differentiation in the small intestine and brain. [provided by MGI curators] |