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Publication : The RAF inhibitor paradox revisited.

First Author  Cox AD Year  2012
Journal  Cancer Cell Volume  21
Issue  2 Pages  147-9
PubMed ID  22340588 Mgi Jnum  J:181465
Mgi Id  MGI:5311489 Doi  10.1016/j.ccr.2012.01.017
Citation  Cox AD, et al. (2012) The RAF Inhibitor Paradox Revisited. Cancer Cell 21(2):147-9
abstractText  The success of the RAF protein kinase inhibitor vemurafenib for the treatment of BRAF mutant metastatic melanoma has produced another poster child for the promise of personalized medicine. However, the results of a recent study also reveal unexpected pitfalls in the application of signal transduction-targeted therapies.
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