| First Author | Rupérez C | Year | 2021 |
| Journal | J Exp Med | Volume | 218 |
| Issue | 5 | PubMed ID | 33635944 |
| Mgi Jnum | J:314430 | Mgi Id | MGI:6724809 |
| Doi | 10.1084/jem.20201206 | Citation | Ruperez C, et al. (2021) Meteorin-like/Meteorin-beta protects heart against cardiac dysfunction. J Exp Med 218(5) |
| abstractText | Meteorin-like/Meteorin-beta (Metrnl/Metrnbeta) is a secreted protein produced by skeletal muscle and adipose tissue that exerts metabolic actions that improve glucose metabolism. The role of Metrnbeta in cardiac disease is completely unknown. Here, we show that Metrnbeta-null mice exhibit asymmetrical cardiac hypertrophy, fibrosis, and enhanced signs of cardiac dysfunction in response to isoproterenol-induced cardiac hypertrophy and aging. Conversely, adeno-associated virus-mediated specific overexpression of Metrnbeta in the heart prevents the development of cardiac remodeling. Furthermore, Metrnbeta inhibits cardiac hypertrophy development in cardiomyocytes in vitro, indicating a direct effect on cardiac cells. Antibody-mediated blockage of Metrnbeta in cardiomyocyte cell cultures indicated an autocrine action of Metrnbeta on the heart, in addition to an endocrine action. Moreover, Metrnbeta is highly produced in the heart, and analysis of circulating Metrnbeta concentrations in a large cohort of patients reveals that it is a new biomarker of heart failure with an independent prognostic value. |
