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Publication : Ontogeny of the cell adhesion molecule L1 in the cerebellum of weaver and reeler mutant mice.

First Author  Bjerregaard A Year  1994
Journal  Neurochem Res Volume  19
Issue  7 Pages  789-93
PubMed ID  7969746 Mgi Jnum  J:19752
Mgi Id  MGI:67885 Doi  10.1007/BF00967445
Citation  Bjerregaard A, et al. (1994) Ontogeny of the cell adhesion molecule L1 in the cerebellum of weaver and reeler mutant mice. Neurochem Res 19(7):789-93
abstractText  The ontogeny of cell adhesion molecule L1 in cerebellum was quantitatively assessed in weaver and reeler mutant mice and in heterozygous litter-mate controls. In the latter the concentration and the amount of L1 both increased from the first postnatal week to become maximum at the second. In contrast, in the weaver and reeler neurologic mutant mice, L1 decreased steadily. The L1 concentration and the amount of L1 was lower in the cerebellum of homozygous mutant mice than in litter-mate controls. The findings are consistent with L1 being a component of axonal plasma membranes. However, no evidence was found of any direct effect of the wv and rl phenotypes on L1 expression.
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