| Primary Identifier | MGI:97439 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 18387 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables G protein-coupled opioid receptor activity. Involved in locomotory behavior; regulation of saliva secretion; and sensory perception of pain. Acts upstream of or within G protein-coupled opioid receptor signaling pathway. Located in plasma membrane. Is expressed in several structures, including brain; early conceptus; gut; limb mesenchyme; and uterus. Human ortholog(s) of this gene implicated in alcohol dependence; alcohol use disorder; depressive disorder; drug dependence (multiple); and opioid abuse. Orthologous to human OPRK1 (opioid receptor kappa 1). PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired response to morphine and an opioid agonist, abnormal pain threshold, and increased litter size. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
