| First Author | Nordeen SK | Year | 1984 |
| Journal | Mutat Res | Volume | 140 |
| Issue | 4 | Pages | 219-22 |
| PubMed ID | 6206393 | Mgi Jnum | J:7561 |
| Mgi Id | MGI:56031 | Doi | 10.1016/0165-7992(84)90081-2 |
| Citation | Nordeen SK, et al. (1984) Evaluations of wasted mouse fibroblasts and SV-40 transformed human fibroblasts as models of ataxia telangiectasia in vitro. Mutat Res 140(4):219-22 |
| abstractText | Fibroblast cultures from wasted mice have been derived and the responses of these cultures to bleomycin treatment or gamma-irradiation have been examined. No differences were observed between wasted fibroblasts and littermate controls in the post-treatment inhibition of DNA replication. In contrast, a human SV-40 transformed ataxia telangiectasia fibroblast line mimicked the abnormal response of primary ataxia telangiectasia fibroblasts to gamma-rays or bleomycin and thus appears to be a useful in vitro model of ataxia telangiectasia. |
