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Protein Coding Gene : Ift88 intraflagellar transport 88

Primary Identifier  MGI:98715 Organism  mouse, laboratory
Chromosome  14 NCBI Gene Number  21821
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0)

Enables kinesin binding activity. Involved in cilium assembly; regulation of autophagosome assembly; and regulation of cilium assembly. Acts upstream of or within several processes, including circulatory system development; nervous system development; and spermatid development. Located in several cellular components, including ciliary base; cytoskeleton; and non-motile cilium. Part of intraciliary transport particle B. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and respiratory system. Used to study autosomal recessive polycystic kidney disease; mitral valve disease; and scimitar syndrome. Orthologous to human IFT88 (intraflagellar transport 88).
PHENOTYPE: Mice homozygous for a null allele display early to mid-gestation lethality, random patterning of the left-right body axis, neural tube defects, pericardial sac expansion, enlarged limb buds, polydactyly, and absent embryonic node cilia. [provided by MGI curators]
  • synonyms:
  • Oak Ridge polycystic kidneys,
  • orpk,
  • Ift88,
  • polaris,
  • MGI:2145834,
  • AW552028,
  • expressed sequence AW552028,
  • IFT88,
  • transgene insert site 737, insertional mutation, polycystic kidney disease,
  • MGD-MRK-15052,
  • Ttc10,
  • tetratricopeptide repeat domain 10,
  • intraflagellar transport 88,
  • Tg737Rpw,
  • fxo,
  • TgN737Rpw,
  • Tg737

Features --> Cross References

Genome

Sequence Feature Displayer

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

1 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

10 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

0 Driver For