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Protein Coding Gene : Calm1 calmodulin 1

Primary Identifier  MGI:88251 Organism  mouse, laboratory
Chromosome  12 NCBI Gene Number  12313
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0)

Predicted to enable several functions, including calcium channel inhibitor activity; enzyme activator activity; and enzyme binding activity. Involved in presynaptic endocytosis. Acts upstream of or within G2/M transition of mitotic cell cycle. Located in myelin sheath and sperm midpiece. Part of voltage-gated potassium channel complex. Is active in calyx of Held. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in catecholaminergic polymorphic ventricular tachycardia 4 and long QT syndrome 14. Orthologous to human CALM1 (calmodulin 1).
PHENOTYPE: Mice homozygous for an amino acid substitution show small body size at a young age but become obese as they age and show hyperactivity, increased exploration in new environment, increased aerobic running capacity, and a slight increase in female heart rate. [provided by MGI curators]
  • synonyms:
  • calmodulin 1,
  • expressed sequence AI461935,
  • expressed sequence AI327027,
  • AI327027,
  • MGI:2144797,
  • MGD-MRK-1734,
  • AI256814,
  • MGI:2144926,
  • MGI:2144778,
  • MGI:2144834,
  • expressed sequence AI256814,
  • Calm1,
  • expressed sequence AL024000,
  • AI461935,
  • AL024000

Features --> Cross References

Genome

Sequence Feature Displayer

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

1 Involved In Mutations

0 Strain

0 Transcripts

1 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

98 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

0 Driver For