| Primary Identifier | MGI:107718 | Organism | mouse, laboratory |
| Chromosome | 15 | NCBI Gene Number | 110082 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables microtubule motor activity. Acts upstream of or within several processes, including determination of left/right symmetry; epithelial cilium movement involved in extracellular fluid movement; and lateral ventricle development. Located in 9+0 motile cilium; 9+2 motile cilium; and axoneme. Part of outer dynein arm. Is expressed in several structures, including gut; male reproductive gland or organ; midbrain; and trachea epithelium. Used to study otitis media; primary ciliary dyskinesia (multiple); tetralogy of Fallot; and visceral heterotaxy. Human ortholog(s) of this gene implicated in Kartagener syndrome and primary ciliary dyskinesia 3. Orthologous to human DNAH5 (dynein axonemal heavy chain 5). PHENOTYPE: Mice homozygous for a disruption in this gene display postnatal lethality, hydrocephalus, respiratory infections, situs inversus and ciliary immotility. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
